Even though researchers are aware about the analgesic outcomes of comparable compounds, it's been difficult to research conolidine due to the fact there isn't plenty of of it available from natural resources. It tends to make up just 0.00014% of the bark of T. divaricata Conolidine be

In the screening test involving in excess of 240 receptors, the researchers uncovered that conolidine demonstrated binding to the ACKR3 receptor in both of those individuals and mice, protecting against ACKR3 from binding to opioid peptides. The opioid method inside the human system comprises